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Chemotherapy

Chemical switch determines if healthy cells are killed

Published in Cancer Weekly, November 19th, 2002

Investigators at Washington University School of Medicine in St. Louis, Missouri have discovered a mechanism that helps explain why healthy cells are not killed by DNA-damaging cancer chemotherapy drugs.

The findings are published in the journal Cell (2002;111(1):51-62).

DNA-damaging agents are the most common kind of drugs used to treat cancer. Like most chemotherapy drugs, these are carried in the blood and travel throughout the body. They work by irreparably gumming up DNA in rapidly dividing tumor cells. That damage then triggers the cells to self-destruct through apoptosis.

The drugs also can harm rapidly dividing...

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