Cancer Gene Therapy

Gene agent inhibits tumor growth through apoptosis

Published in Cancer Weekly, November 19th, 2002

by Sonia Nichols, senior medical writer - Adenovirus-mediated delivery of the p202 gene can cause cancer cells to self-destruct.

"p202, a mouse interferon (IFN)-inducible protein, is a member of the 200-amino acid repeat family," explained investigators who work at the University of Texas M.D. Anderson Cancer Center in Houston.

Yi Ding and colleagues have used p202 gene transfer to stimulate programmed cell death, or apoptosis in cell cultures and in xenograft models, according to their report.

The investigators elected to use an adenoviral (Ad) vector for gene delivery. They tested Ad-p202 in human breast cancer cells as well as...

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Source: Cancer Weekly (2002-11-19)

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