Published in Cancer Weekly, November 26th, 2002
"Cancer cells frequently show high constitutive activity of the antiapoptotic transcription factor nuclear factor kappaB (NF-kappaB), which results in their enhanced survival," explained Frank Pajonk and colleagues at the Radiological University Clinic in Freiburg, Germany and the University of California at Los Angeles. "Activation of NF-kappaB classically depends on degradation of its inhibitor IkappaBalpha by the 26s proteasome."
The HIV protease inhibitor saquinavir also blocks human proteasome...
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