Cancer Therapy

AntiHIV agent active against malignant cells

Published in Cancer Weekly, November 26th, 2002

by Michael Greer, senior medical writer - An agent used to fight HIV infection may also be effective for uninfected cancer patients, researchers say.

"Cancer cells frequently show high constitutive activity of the antiapoptotic transcription factor nuclear factor kappaB (NF-kappaB), which results in their enhanced survival," explained Frank Pajonk and colleagues at the Radiological University Clinic in Freiburg, Germany and the University of California at Los Angeles. "Activation of NF-kappaB classically depends on degradation of its inhibitor IkappaBalpha by the 26s proteasome."

The HIV protease inhibitor saquinavir also blocks human proteasome...

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Source: Cancer Weekly (2002-11-26)

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