Cancer Gene Therapy

Experimental vaccine induces protection against some glioblastoma cells

Published in Cancer Weekly, December 3rd, 2002

Wistar Institute researchers have shown that "[i]noculation of mice with a recombinant vaccinia virus expressing the full-length mouse wild-type p53 protein (Vp53-wt) ...[induces] partial protection against peripheral challenge with a mouse glioblastoma cell line, termed GL261, expressing high levels of nuclear, endogenous wild-type p53."

"In vivo experiments with knockout (KO) mice and mice treated with depleting doses of antibodies specific to lymphocyte subsets revealed that vaccine efficacy depended on CD4+ and CD8+ T cells as well as on natural killer (NK) cells," wrote M. Blaszczykthurin and colleagues.

"Vp53-wt virus-vaccinated mice that...

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Source: Cancer Weekly (2002-12-03)

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