Cancer Metastases

Does neoangiogenesis play key role in spread from unknown primary tumors?

Published in Cancer Weekly, December 17th, 2002

Pathologists in India have put forth a hypothesis about metastases from unknown primary (MUP) tumors.

They suggest a "plausible role of neoangiogenesis, as a central theme in the development of MUPs..."

According to K.N. Naresh and colleagues, Tata Memorial Hospital, Maharashtra, "Invasive cancers, which cannot or do not switch to the angiogenic phenotype, remain subclinical. In situations where a nonangiogenic tumor attempts to grow beyond the volume that can be supported by the vasculature, marked apoptosis and cell turnover result. Tumors with a high cell turnover are biologically advanced. Thus, such subclinical tumors acquire a metastatic...

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Source: Cancer Weekly (2002-12-17)

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