Metastasis

Tumor-derived growth factor links cancer to lymph node involvement

Published in Cancer Weekly, December 17th, 2002

by Sonia Nichols, senior medical writer - A variant of vascular endothelial growth factor (VEGF) may be responsible for dispersing cancer cells by increasing peritumor lymphatic drainage, medical researchers report.

Investigators have identified a direct link between VEGF165 and lymphatic drainage around tumors, suggesting a role for the growth factor's involvement in cancer cell dissemination to nearby lymph nodes.

Hagit Dafni and colleagues at the Weizmann Institute of Science in Rehovot, Israel, used imaging studies to evaluate VEGF-induced hyperpermeability and the possibility of tumor cell conveyance to sentinel lymph nodes.

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Source: Cancer Weekly (2002-12-17)

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