Cancer Gene Therapy

DNAzymes targeting VEGFR2 inhibit angiogenesis

Published in Cancer Weekly, December 24th, 2002

The antiangiogenic activity of DNAzymes give them potential as antitumor agents, say pathologists at the University of Maryland.

"The vascular endothelial growth factor receptor (VEGFR) is an important angiogenic target for cancer gene therapy. In this study, we designed an mRNA-cleaving oligodeoxynucleotide that targets the VEGF receptor 2 (VEGFR2) transcript (VEGFR2 DNAzyme). This DNAzyme was found to digest efficiently mRNA substrates of VEGFR2 in a concentration- and time-dependent manner," stated L. Zhang and colleagues.

Their study "also showed that the DNAzyme induces apoptosis and markedly inhibits endothelial cell growth compared with a...

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Source: Cancer Weekly (2002-12-24)

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