Gliomas

Suicide gene therapy sustains antitumor activity in murine model

Published in Cancer Weekly, December 24th, 2002

According to a study from Japan, "Gene therapy using adenoviral (Ad) vector containing herpes simplex virus thymidine kinase (AxCAHSV-tk) followed by the administration of ganciclovir (GCV) has been a promising therapy for cancer, including malignant gliomas. However, there remain numerous problems to overcome, such as the high immunogenicity and toxicity of Ad vector."

M. Mizuno and colleagues, Nagoya University, conducted experiments in mouse models of subcutaneous and intracranial gliomas to see if their original cationic liposomes conjugated with Ad vectors lowered viral antigenicity and sustained antitumor activity in murine models of experimental subcutaneous and...

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Source: Cancer Weekly (2002-12-24)

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