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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . December 31st, 2002

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Lung Cancer - Enzyme controls several mechanisms of lung tumorigenesis

Stem Cell Transplantation - Posttranslant delirium common in cancer patients

Breast Cancer - Combined antiangiogenic and immune therapy may hold promise

Cancer Vaccine - Multiantigenic carbohydrate vaccines stimulate strong humoral response in mice

Gastric Carcinoma - Antisense human telomerase reverses malignant character of gastric cancer

Leukemia - New drug significantly improves survival even for patients with late-stage disease

Melanoma - Potential molecular marker identified

Prostate Cancer - Double suicide gene therapy augments radiation treatment in mouse model

Acute Myeloid Leukemia - Leptin blockade inhibits animal model of leukemia

Antiangiogenesis - Orally active inhibitor of EGF signaling has potential for cancer therapy

Antisense Technology - Antisense plasmid of macrophage MIF suppresses tumor growth

Appointments - Dr. David Cox named CEO of KS Avicenna

Appointments - Spears named chairman, CEO

B-Cell Lymphoma - Immunogenicity of a plasmid DNA vaccine encoding chimeric idiotype studied

Brain Tumors - Intratumoral injection of dendritic and irradiated glioma cells studied

Breast Cancer - CRE-decoy aptamer showed significant activity in hormone-resistant breast cancer

Breast Cancer - Diamond DX FFDM system to be demonstrated

Breast Cancer - Elderly women undertreated?

Breast Cancer - Hormone replacement therapy link found

Breast Cancer - Instrumentarium Imaging, Suros pair up products

Breast Cancer - Novel mechanism of BRCA1 mutation-based tumorigenesis elucidated

Breast Cancer - Preliminary findings reported from hard-copy versus soft-copy mammography study

Breast Cancer - Study confirms risk of continuous combined hormone therapy

Breast Cancer - Study hints demographic link in California county

Breast Cancer - iCAD subsidiary launches mammography film digitizer

Cancer Diagnostics - Molecular tests lead the way in growth of $3.5 billion cancer IVD market

Cancer Drug Mechanism - X-ray based 3-D image shows topotecan mechanism

Cancer Therapies - BAY 43-9006, ONYX-015 moving forward

Cancer Vaccine - G17DT safe in phase II clinical trials and increases survival of pancreatic cancer patients

Cancer Vaccine - Heat shock protein complex successfully treats subset of malignant melanoma patients

Cancer Vaccine - New approach helps identify peptide-based immunotherapeutics

Cancer Vaccine - Vaccinia melanoma cell lysates do not extend survival of melanoma patients

Carcinogens - U.S. agency finds highly variable levels of worrisome chemical in foods

Cervical Cancer - Screening guidelines support HPV testing

Cervical Cancer - Study finds ethnicity link

Chemotherapy Side Effects - NDA filed for palonosetron

Colon Cancer - Insulin-like growth factors and receptor involved in angiogenesis, metastasis

Colon Cancer - Link to common human virus found

Colon Cancer - Suppression of proline-directed protein kinase F-A could have therapeutic value

Diabetic Retinopathy - Technique to diagnose skin cancer could also help prevent blindness

Disease Associations - Blood transfusion linked to liver cancer risk in a high-endemic area of Japan

Finance - First quarter net losses due to company expansion

Gliomas - Antisense oligonucleotide sensitizes cancer cells to ionizing radiation, drugs

Gliomas - Transcription factor overexpression leads to bax-independent cell death

Gliomas - Tumor-sensitized lymphocytes are immunotherapeutic in rat model

HIV/AIDS Cancer - Rituximab effective against CD20+ non-Hodgkin lymphoma cells

Helicobacter Pylori - Ulcer-causing pathogen uses hydrogen for energy

Hepatocellular Carcinoma - IFN therapy doesn't prevent liver cancer in HCV-compensated cirrhosis

Human Papillomavirus - HPV vaccine offers hope

Human Papillomavirus - Tumor model established in HLA-A*0201 transgenic mice to test vaccines

Hypoxia - Pancreatic ductal carcinomas reveal protein-specific angiogenesis

Imaging - Mammograms may detect heart disease

Imaging Technology - Novel tracer developed for imaging VEGF in vivo using PET

Melanoma - Adjuvant immunotherapy using vaccinia viral lysates found ineffective

Melanoma - Strong VEGF expression in malignant tumors aids differentiation of lesions

Metastasis - Cancer's deadly signature revealed by gene chip technology

Multiple Myeloma - Thalidomide-like compound shows early promise

Non-Hodgkin Lymphoma - Genitope initiates clinical trial to evaluate GTOP-99 following use of Rituxan

Non-Hodgkin Lymphoma - Personalized vaccine for NHL being tested at New York Weill Cornell

Non-Small Cell Lung Cancer - Impact of adenovirus-vectored gene therapy on tumor angiogenesis studied

Nutrition - Clinical trial looks at using nutrients to prevent cancer

Ovarian Cancer - AP5280 was well tolerated at platinum doses in phase I trial

Ovarian Cancer - Combined PET-CT better at detecting metastases

Pancreatic Cancer - Antigastrin immunogen induces immune response in phase II study

Pancreatic Cancer - Gene transfer encourages longer survival, fewer pancreatic tumors

Pancreatic Cancer - NDA for Orathecin gets fast-track designation

Pancreatic Cancer - NK4's antiangiogenic activity holds promise for gene therapy

Pancreatic Cancer - T-cell targeting immunotherapy "still a hypothesis"

Partnerships - $2.1M clinical consulting contracts announced

Prostate Cancer - Antitumor reactivity of peptide-induced CTLs important for epitope selection

Prostate Cancer - Company announces launch of phase I clinical trial of MLN2704

Prostate Cancer - Gene therapy may be a safe and effective adjuvant to radiation treatment

Prostate Cancer - Novel human prostate-specific antigen may have diagnosis, therapy applications

Prostate Cancer - Routine screening may not improve outcomes

Solid Tumors - Plasma VEGF levels have prognostic value in AML, not myelodysplastic syndromes

Stem Cell Transplantation - Reduced-intensity conditioning lowers viral respiratory infection mortality

Stomach Cancer - Lipid-mediated ICAM-1 gene transfection suppresses peritoneal metastasis

Stress - Ability to cope may play role in cancer progression

Tumor Blood Vessels - Research continues into anionic phospholipids

Uterine Cancer - Possible association between angiogenesis and early-stage cancer detected

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