Lung Cancer

Enzyme controls several mechanisms of lung tumorigenesis

Published in Cancer Weekly, December 31st, 2002

by Sonia Nichols, senior medical writer - Researchers in Colorado think inducible nitric oxide synthase (iNOS) inhibitors could be used for controlling lung cancer.

Their theory is based on a study of iNOS expression and activity in the lungs of wild-type and iNOS (-/-) knockout mice bearing lung tumors.

"Inducible nitric oxide synthase (iNOS) content is elevated in human lung adenocarcinomas, and lung cancer patients exhale more nitric oxide (NO) than healthy individuals," Lori R. Kisley and colleagues at the University of Colorado Health Sciences Center in Denver, Colorado explained in Cancer Research.

Urethane, used in...

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Source: Cancer Weekly (2002-12-31)

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