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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . January 7th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Acute Myeloid Leukemia - Growth factor antagonists may reverse course of hematologic cancer

Head and Neck Cancer - Adenoviral transfer of p27 gene decreases squamous cell carcinoma

Breast Cancer - Herceptin pretreatment enhances Taxol's effect in ErbB2-overexpressing cells

Cancer Vaccine - Pancreatic cancer research should focus on antigen presentation, targeted drug delivery

Cell Biology - Scientists discover mechanism by which cells rid themselves of damaged proteins

Head and Neck Cancer -  p53 Mutation may contribute to tumor progression

Hepatocellular Carcinoma - Did nuclear bomb increase hepatitis C-related liver cancer risk?

Prostate Cancer Risk Factor - Diabetes decreases prostate cancer risk

Adoptive Immunotherapy - Effective tumor targeting visualized by redirected CD8+ natural killer T cells

Antiangiogenic Gene Therapy - Kallistatin is a new inhibitor of tumor neovascularization and growth

B-Cell Chronic Lymphocytic Leukemia - Enhanced bone marrow angiogenesis may have prognostic value in early disease

Brain Cancer - Glioblastoma in Asian population shows evidence of a distinct genetic pathway

Brain Metastases - Update provided on regulatory status of RSR13

Brain Tumor - Ganciclovir pellets enhance effects of suicide gene therapy

Breast Cancer - Change on enzyme gene may associate with invasive disease

Breast Cancer - Improvements in disease-free survival reported with adjuvant dose-dense chemotherapy

Breast Cancer - New 3-D mammography system may improve breast imaging

Breast Cancer - Reconstructive breast surgery rates low in Canada

Breast Cancer - Study shows TS-2000 system 100% sensitive in detecting breast lesions under 1 cm

Breast Cancer - Technique reveals drug resistance in tumors, could prevent unnecessary chemo

Breast Cancer - VIDAR unveils newest film digitizer

Breast Cancer - Vaccine generates strong immune response in women with advanced disease

Breast Cancer - Zometa significantly reduces bone complications

Cancer Gene Therapy - Adenoviral transduction of tumor cells induces apoptosis in cocultured T cells

Cancer Gene Therapy - CD40-targeted adenoviral vectors show promise for tumor immunotherapy

Cancer Gene Therapy - Coactive strategy boosts IL-18 antitumor effect

Cancer Immunotherapy - Phage-display selection technique for specific human scFv antibody described

Cancer Immunotherapy - Recombinant E. coli vaccine promotes MHC class I-dependent antigen presentation

Cancer Immunotherapy - Two antigens may be targets in desmoplastic small round cell tumor

Cancer Metastases - FGF-like autoantibodies may arise spontaneously in hypercalcemia

Cancer Pain - RF Technology reduces pain in bone cancer patients

Cancer Targets - Researchers solve 3-D atomic structure of Aurora-2 kinase

Cancer Therapy - Additional phase I data presented on liposomal antisense agent

Cancer Therapy - Clinical data on VNP40101M reported at EORTC-NCI-AACR meeting

Cancer Therapy - Pilot program explores viability of cell-penetrating peptide-based drugs

Cancer Therapy - Preclinical data shows synergy of TLK286 in combination with chemo drugs

Cancer Vaccine - DNA vaccine elicits humoral and cellular immune responses in lymphoma patients

Cancer Vaccines - Tumor cell lysate-pulsed DC effective for T-cell lymphoma immunotherapy

Chronic Lymphocytic Leukemia - Genasense shows single-agent activity in patients with advanced CLL

Endocrinology - Diagnostic, therapeutic uses beyond thyroid seen for sodium iodide symporter

Epidemiology - Hepatitis C virus presents risk for liver cancer in adults with AIDS

Hairy Cell Leukemia - Data presented on Nipent shows its capability as a franchise compound

Health Information - No more medical roulette: Publisher says internet will change in 2003

Hodgkin Lymphoma - Phase I trial data on novel bispecific molecule H22xKi-4 reported

Liver Cancer - Aflatoxin exposure adds to hepatocellular carcinoma risk for HBV infected

Liver Cancer - Hepatitis-associated cancer prevented by anti-Fas ligand antibody therapy

Liver Cancer - Real-time PCR of HBV DNA in tumorous and surrounding tissue yields useful data

Lung Cancer - Clinical data: RF technology effective in treating cancerous lung tumors

Lung Cancer - M2BP has use as a tumor marker and target antigen in cancer immunotherapy

Lung Cancer - New evidence links smoking and lung cancer in women

Lymph Node Disease - Research: Combidex can detect lymph node disease in prostate and renal cancer

Lymphocytic Leukemia - Phase II study data reported on rituximab + fludarabine immunotherapy

Lymphoma - Human antibody MDX-060 demonstrates antitumor activity in animal models

Malignant Glioma - Phase I/II data presented for IL13-PE38

Melanoma - PHLDA1/TDAG51 downregulation contributes to tumor growth, metastases

Multiple Myeloma - Farnesyl transferase inhibitors may have therapeutic potential

Multiple Myeloma - Novel drug continues to show promise in early study

Myelodysplastic Syndrome - Studies suggest decitabine is effective in elderly MDS patients

Neurodegeneration - Tumor suppressor protein capable of igniting neuron differentiation

Non-Hodgkin Lymphoma - Positive pivotal phase II/III clinical trial results achieved for Onco TCS

Non-Hodgkin Lymphoma - Trial evaluates dosing and scheduling of adjuvant administered with personalized immunotherapy

Non-Small Cell Lung Cancer - FDA approves Taxotere for first-line treatment of patients

Orthodontics - Nitric oxide indicted in angiogenesis of oral dysplasia

Pharmacodynamics - Antiangiogenic agent, Neovastat, induces endothelial cell apoptosis

Prostate Cancer - Angiogenesis, proliferation, and apoptosis could be biomarkers for therapy

Prostate Disease - Antithrombin recognized as antiangiogenesis source in low-grade tumors

Quality Assurance - Assessments help physicians become more aware of quality-of-life issues

Renal Cell Carcinoma - Serum angiogenic activity isn't correlated with prognosis

Rhadbdomyosarcoma - More rare childhood cancer cases reported in Nevada

Smoking Cessation - Self-help program for pregnant smokers is ineffective

Stem Cell Transplantation - Human leukocyte antigen alleles affect graft-versus-host disease risk

Stem Cell Transplantation - Interleukin-18 doesn't disrupt antileukemia effects

Technology - New system speeds mapping of blood vessel networks in live tumors

Tumor Marker - Soluble enzyme N/CD13 associates with tumor load in cancer patients

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