Cancer Gene Therapy

Coactive strategy boosts IL-18 antitumor effect

Published in Cancer Weekly, January 7th, 2003

According to recent research from Japan, "Interleukin-18 is a potent cytokine expressed early in the immune response following cleavage in activated composes. We have investigated the in vivo antitumor effects of intratumoral (i.t.) administration of an adenoviral vector expressing biologically active murine interleukin (IL)-18 (Ad.PTH.IL-18)."

F. Tanaka and colleagues, University of Tokyo, reported, "Substantial antitumor effects were observed when established MCA205 fibrosarcoma was treated in syngeneic immunocompetent mice with intratumoral injection of Ad.PTH.IL-18 (p=0.0025 versus control vector treatment), generating potent cytotoxic T lymphocytes (CTLs) in...

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Source: Cancer Weekly (2003-01-07)

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