Neuroblastoma

In vivo angiogenic activity correlates with MYCN oncogene overexpression

Published in Cancer Weekly, January 14th, 2003

"Neuroblastoma (NB) is the most common malignant solid tumor in early childhood. Amplification of the MYCN oncogene is associated with a more malignant course of disease and poor outcome. The role that MYCN plays in the regulation of angiogenesis in NB remains unclear," researchers in Italy say.

"To better elucidate this matter, fresh biopsy samples from 21 patients - 10 with MYCN-amplified tumors (defined as having > 10 copies of the oncogene) and 11 with nonamplified tumors - were tested for their angiogenic capacity using the chick embryo chorioallantoic membrane assay, a useful model for such investigation.

"Moreover, using the same...

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Source: Cancer Weekly (2003-01-14)

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