Published in Cancer Weekly, January 21st, 2003
M.S. Tsai and colleagues, Evanston NW Healthcare Research Institute, Indiana, previously demonstrated Cyr61 "is overexpressed in invasive and metastatic human breast cancer cells and tissues." In their current study, they "investigated whether Cyr61 is necessary and/or sufficient to bypass the 'normal' estrogen (E2) requirements for breast cancer cell growth."
They reported finding "that Cyr61 is sufficient to induce MCF-7 cells to grow in the absence of E2. Cyr61-transfected MCF-7 cells (MCF-7/Cyr61) became...
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