Cancer Vaccines
HER-2-derived recombinant antigens engineered for antitumor immunotherapy
Published in Cancer Weekly, January 21st, 2003
"Certain types of malignant tumors overexpress HER-2, a transmembrane glycoprotein of the class I receptor tyrosine kinase erbB family. To develop an effective HER-2 vaccine for the selective immunotherapy of these malignancies, we have genetically engineered fusion proteins containing portions of extra- and intracellular HER-2 domains," scientists with Dendreon Corp., Seattle, Washington, reported.
"Activated dendritic cells (DC) cocultured with these novel antigens (Ag) could induce potent responses of Ag-specific T-cell lines in vitro and a protection against HER-2-expressing tumor in vivo," they said.
D. Vidovic and colleagues reported that...
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Source: Cancer Weekly (2003-01-21)
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