Renal Cell Carcinoma

Autologous monocyte-derived dendritic cell-based immunotherapy well tolerated

Published in Cancer Weekly, January 21st, 2003

Data on the feasibility and safety of dendritic cell-based immunotherapy in patients with metastatic renal cell carcinoma were reported recently by urologists in Austria.

"Patients with metastatic RCC (n=35) received vaccinations (i.v. or i.d.) of CD83+ autologous monocyte-derived dendritic cells (moDCs). MoDCs were loaded with lysate of cultured autologous or allogeneic permanent tumor cells (A-498) as well as keyhole limpet hemocyanin as control and helper antigen. Maturation of moDCs was induced by a combination of tumor necrosis factor alpha, interleukin 10, interleukin 6, and prostaglandin E-2." wrote L. Holtl and colleagues, Innsbruck University.

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Source: Cancer Weekly (2003-01-21)

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