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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . February 4th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Cell Biology - Researchers identify protein that kills cancer cells

Molecular Biology - Cancer molecule mystery solved

Abdominal Cancer - Novel treatment may improve survival rates in patients with abdominal cancer

Breast Cancer - Treatments and outcomes differ widely among women of different races

Cancer Therapy - Novel heparin-binding domain might direct therapeutic delivery

Gastric Cancer - Human cancers made to express angiostatin block tumor growth

Acute Lymphoblastic Leukemia - Reactive oxygen species play role in pathway of vincristine-induced apoptosis

Acute Myeloid Leukemia - Bone marrow transplant not appropriate for all patients

Antisense Gene Therapy - Decoy oligonucleotides favor tumor cells over normal tissues

Appointments - Former WebMD executive producer joins NewsRx

Basal Cell Cancer - Elimination of biopsies possible with real time diagnosis by scanning microscopy

Benign Prostatic Hyperplasia - Levels of SHBG, sex-steroid hormones correlate with volume in African Americans

Bladder Cancer - Inhibitor of XIAP could be used in treating transitional cell cancer

Bladder Cancer - Reasons found for differing quality of recovery following various treatments

Bladder Tumors - Tumor supressor gene DBCCR1 linked to upregulation of ASML3a

Blood Testing - PCR-based assays may aid medullary thyroid cancer treatment

Bloom Syndrome - Researchers discover novel function of gene often associated with cancer

Bone Cancer - Fine-needle aspiration a cost-effective, accurate tool in diagnosis

Brain Cancer - Survivors at risk for endocrine, cardiovascular diseases

Brain Metastases - Aggressive treatment supported for Class 1, 2 patients with controlled primary

Brain Tumors - Whole-body F-18-FDG PET can differentiate between metastatic and primary lesions

Breast Cancer - Doxorubicin/docetaxel sequence may be active first-line treatment of metastasis

Breast Cancer - Drinking increases risk

Breast Cancer - HLA-A3-restricted epitopes show potential for treatment and prevention

Breast Cancer - Independent component analysis may help identify lesion morphology

Breast Cancer - Isolated limb perfusion with melphalan may be successful in femoral metastasis

Breast Cancer - Karyotypic aberrations related to disease-free survival

Breast Cancer - Long-term use of continuous, combined hormone replacement therapy increases risk

Breast Cancer - Mitotic activity index independent prognostic factor for relapse free survival

Breast Cancer - Oral contraceptives may increase risk in BRCA1 but not BRCA2 mutation carriers

Breast Cancer - Preoperative assessment MR imaging unnecessary when mammography, sonography used

Breast Cancer - Recurrence treated by brachytherapy following lumpectomy can preserve the breast

COX-2 - Enzyme expression linked to angiogenesis in intestinal polyps

Cancer Biomarkers - Glomeruloid microvascular proliferations suggest nature of cancer aggression

Cancer Metastasis - Angiogenesis and tumor growth thrive in fibrinogen-deficient mice

Cancer Research - Dual-specificity phosphatases studied as targets for antineoplastic agents

Cancer Research - Researcher investigates cell proliferation control

Cancer Research - Tumor regression mechanisms by IL-13 receptor-targeted cancer therapy clarified

Cancer Therapy - Promising cancer-fighting candidates emerge from tropical ocean "mud"

Cancer Therapy - Search for cancer cures turns to deep ocean

Carcinogens - Rapid spectrophotometric method developed to measure glutathione S-transferase

Cell Biology - Too much oxygen on the bench? New study suggests so

Cervical Cancer - Cervical keratinocyte gene changes linked to human papillomavirus 16

Cervical Cancer - Spiral-shaped ectocervical brush is as good as biopsy punch in diagnosis

Cervical Carcinoma - Higher unexpected morbidity found following radiotherapy

Chemotherapy - N-butyl cyanoacrylate used successfully to fix catheter tip in arterial infusion

Childhood Cancer - Gram-negative bacteremia causes most mortality in neutropenic patients

Colon Cancer - Cytotoxic solution used for rectal washout can be extended to the whole colon

Colon Cancer - Iron overload gene tied to increased risk

Colonoscopy - Magnetic endoscope imaging is a new technique for localizing colonic lesions

Colorectal Cancer - Angiogenic factors mark invasive potential of advanced colorectal malignancy

Colorectal Cancer - Dietary folate may play a favorable role in carcinogenesis

Colorectal Cancer - Many types of GI complications resulting from flexible sigmoidoscopy

Colorectal Cancer - Peritoneal carcinomatosis cases have generally poor prognosis

Cytopathology - Fine-needle aspiration is valuable in diagnosing primary of soft-tissue lesions

Desmoplastic Neurotropic Melanoma - Sucessful head and neck radiation therapy for unresectable recurrence

Diagnostic Markers - Spectroscopy method for quantification of lysophosphatidylcholine

Drug Metabolism - The p35 gene augments cytochrome P450 gene-directed bystander effects

Endometrial Cancer - E-cadherin expression correlated most with endometrioid carcinoma form

Fine-Needle Aspiration - Other information helps identify thoracic, retroperitoneal spindle-cell lesions

Gastric Adenocarcinoma - Alteration in paranuclear E-cadherin molecule may be early change in progression

Gastric Cancer -  Helicobacter pylori CagA protein may alter host transcription, cytoskeleton

Gastrinoma - Calcium gluconate highly sensitive, specific for localization

Gene Signaling - Loss of prostaglandin E-2 receptor subtype correlates with invasion

Gene Targets - Chelator induces growth inhibition pathways in cancer cell lines

Genomics and Genetics - Proteins restrict ECB-dependent transcription to M/G1 phase of the cell cycle

Glioma - 3-T MR spectroscopy separates recurrent tumors from previous radiation effects

Gliomatosis Cerebri - Distant tumors can share a common clonal origin

HIV/AIDS Cancer - Real-time PCR assay enables human herpesvirus 8 DNA quantitation in biological fluids

HIV/AIDS Therapy - Ritonavir has anticancer effects

Head Neck Cancer - Sentinel node biopsy can upstage the clinically N0 neck in head and neck cancer

Head and Neck Cancer - Function, QOL decreases following radioprotective treatment with misoprostol

Head and Neck Cancer - Pimonidazole a prediction tool for treatment selection, outcomes

Infectious Disease - Human polyomavirus JCV linked to colon cancer

Intraocular Melanoma - Palladium radiotherapy may provide better long-term visual function

Ionizing Radiation - Increased incidence of parathyroid adenomas in adults following exposure

Kidney Cancer - Multifocal lesions are clonal in origin as determined by microsatellite analysis

Laparoscopic Surgery - Laparoscopic abdominoperineal resection of the rectum is advantageous

Laparoscopy - Male sexual dysfunction found in some cases following rectal cancer surgery

Liver Cancer - Left gastric artery approach works best in embolization for chemotherapy

Liver Cancer - Prognostic variables for cases with additional cirrhosis at hepatic resection

Lung Cancer - Benzyl isothiocyanate inhibits polycyclic aromatic hydrocarbon tumorigenesis

Lung Cancer - Half of British workforce worried by workplace smoking

Lung Cancer - Insulin-like growth factor-binding protein-3 associates with cancer survival

Lung Cancer - Screening and early diagnosis of lung cancer may be crucial for survival

Lung Cancer - Tumor suppressor gene product p27(KIP1) has prognostic significance

Lymphoma and Leukemia - Low-dose, local radiotherapy for palliation of cancerous masses very effective

Malignant Melanoma - HDM2 protein overexpression may be independent predictor of survival, prognosis

Malignant Parotid Oncocytoma - Spread through the mastoid cells may cause dural extracerebellar metastasis

Melanocytic Matricoma - Development of rare lesion may have been influenced by sunlight

Melanoma - Presence of certain tumor markers could signal best results for vaccine

Meningioma - Differential expression of human 5S snoRNA genes may relate to carcinogenesis

Merkel Cell Carcinoma - Mohs surgery outcomes are similar with or without adjuvant radiation

Metastatic Cancer - Cystic change in lymph nodes can cause errors in fine needle aspiration cytology

Microhematuria - Use of computerized tomography has better yield, makes nonurological diagnoses

Multiple Myeloma - Thalidomide therapy may lengthen survival

Nasopharyngeal Radium Irradiation - No evidence of elevated risk of head, neck tumors, skin cancer, thyroid disease

Non-Hodgkin Lymphoma - Alterations in the BZLF1 promoter can subclassify Epstein-Barr Virus diseases

Non-Hodgkin Lymphoma - Phase II cancer compound licensed

Obesity Survival and Mortality - Researcher discusses possible mechanisms involved in the link between obesity and cancer

Oligodendroglioma - Postoperative radiotherapy may be useful after surgical excision

Optic Nerve Sheath Meningioma - Stereotactic fractionated radiotherapy holds therapeutic promise

Organ Donation - Tumor and other disease transmission risk by kidney transplantation is small

Ovarian Cancer - New murine model enables study of growth factor in gynecological cancer

Ovarian Cancer - Tumors attacked by immune system respond better to therapy

Pain Medicine - Nonsteroidal anti-inflammatory drug use appears to reduce colorectal adenomas

Penile Carcinoma - Recurrence rates after Nd:YAG laser treatment comparable to partial amputation

Peritoneal Metastasis - Incomplete resection provides significantly worse prognosis

Preventative Screening - Certain women in northern British Columbia have lower participation, higher risk

Prostate Cancer - Androgen receptor expression induces production of fibroblast growth factors

Prostate Cancer - For potential cure by irradiation, a PSA nadir must be achieved within 5 years

Prostate Cancer - Hypothalamic-pituitary-gonadal hormone axis affected by radical prostatectomy

Prostate Cancer - MAPK signaling pathway an essential factor for some prostate cancers

Prostate Cancer - Maspin expression is possible inverse marker for all stages of disease

Prostate Cancer - PSA protein catalog may be useful for analysis of differences among forms

Pulmonary Medicine - CT can help distinguish inflammatory small-vessel diseases of the lung

Rectal Cancer - Epidermal growth factor receptor predictive of lower response to radiotherapy

Renal Cancer - Clonal origin shown in asynchronous bilateral tumors indicates metastasis

Renal Cancer - Normal kidney parts could be mistaken for neoplasia on frozen section evaluation

Renal Cancer - Standardized nuclear grades are more predictive of death

Retinoblastoma - Irradiation by orbital brachytherapy improves morbidity and mortality risk

Risk Factor - Incidence and spectrum of malignant disease increased among dialysis patients

Skin Cancer - Observations associating sunlight exposure with development noted in early 1900s

Skin Cancer - Syndecan-1 is strongly expressed in the hair follicle

Solid-Pseudopapillary Tumor of the Pancreas - Cytologic features allow for diagnosis even in unusual presentations

Spinal cord hemangioblastoma - Total removal resulted in a better outcome

Squamous Cell Cancer - Cisplatin, vinorelbine active for recurrent, metastatic carcinomas of head, neck

Squamous Cell Carcinoma - Nasolabial flap reconstruction of the floor of the mouth functional alternative

Systemic Lupus Erythematosus - Cancer therapy may offer patients new hope

Testicular Cancer - Cis-diamminedichloroplatinum, vinblastine, bleomyein combo is major advance

Thyroid Cancer - Galectin-3 is a reliable diagnostic marker of medullary carcinoma

Thyroid Cancer - TGF-beta family members are potential targets for novel anticancer treatment

Tuberous Sclerosis - Facial lesions need microscopic examination for adequate surgical treatment

Tumor Invasion - MMP-9 activation by tumor trypsin-2 enhances invasion of tongue cancer cells

Urothelial Cancer - Chromosome 5p13-12 data can predict adverse prognosis regardless of stage/ grade

Venous Thromboembolism - Factor V Leiden mutation does not increase risk in gynecologic oncology patients

Von Hippel-Lindau - Neuroendocrine pancreas tumors' have characteristic appearance

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