Ovarian Cancer

New murine model enables study of growth factor in gynecological cancer

Published in Cancer Weekly, February 4th, 2003

Researchers have established a new murine model that improves the study of ovarian cancer.

"Vascular endothelial growth factor (VEGF) performs multifaceted functions in the tumor microenvironment promoting angiogenesis, suppressing antitumor immune response, and possibly exerting autocrine functions on tumor cells. However, appropriate syngeneic animal models for in vivo studies are lacking. Using retroviral transfection and fluorescence-activated cell sorting, we generated a C57BL6 murine ovarian carcinoma cell line that stably overexpresses the murine VEGF164 isoform and the enhanced green fluorescent protein," reported researchers from the United States.

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Source: Cancer Weekly (2003-02-04)

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