Cell Biology

Researchers identify protein that kills cancer cells

Published in Cancer Weekly, February 4th, 2003

Researchers at Washington University School of Medicine in St. Louis have found that a protein called cytidine uridine guanosine binding protein-2 (CUGBP2) can destroy several different types of cancer cells. When the team inserted the protein into cultured tumor cells, more than 70% self-destructed.

The researchers found that CUGBP2 helps regulate production of cyclooxygenase-2, (COX-2), which is better known as a key culprit in arthritis.

"The gene that produces COX-2 is turned on very early in cancer, so there has been a lot of research to see whether interfering with it might be an effective therapy," said principal investigator Shrikant Anant,...

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Source: Cancer Weekly (2003-02-04)

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