Breast Cancer

Oral contraceptives may increase risk in BRCA1 but not BRCA2 mutation carriers

Published in Cancer Weekly, February 4th, 2003

According to a study from Canada, "oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2.

"We performed a matched case control study on 1311 pairs of women with known deleterious BRCA1 and/or BRCA2 mutations recruited from 52 centers in 11 countries. Women who had been diagnosed with breast cancer were matched to control subjects by year of birth, country of residence, mutation (BRCA1 or BRCA2), and history of ovarian cancer. All study...

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Source: Cancer Weekly (2003-02-04)

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