HIV/AIDS Therapy

Ritonavir has anticancer effects

Published in Cancer Weekly, February 4th, 2003

"Ritonavir is an HIV protease inhibitor used in the therapy of HIV infection. Ritonavir has also been shown to inhibit the chymotrypsin-like activity of isolated 20S proteasomes," according to recent research from Germany.

S. Gaedicke and coauthors showed that "ritonavir, like classical proteasome inhibitors, has antitumoral activities."

"In vitro, ritonavir strongly reduced the rate of proliferation of several tumor cell lines and induced their apoptosis. Nontransformed cell lines and terminally differentiated bone-marrow macrophages were comparatively resistant to the apoptosis-inducing effect," according to study data. "In vivo, ritonavir,...

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Source: Cancer Weekly (2003-02-04)

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