Acute Lymphoblastic Leukemia

Reactive oxygen species play role in pathway of vincristine-induced apoptosis

Published in Cancer Weekly, February 4th, 2003

According to recent research from Netherlands, "Vincristine (VCR), a microtubule interfering anticancer agent, plays a key role in the treatment of childhood acute lymphoblastic leukaemia (ALL). The route of VCR-nduced apoptosis in ALL cells is not well defined.

"We demonstrated caspase-9 and -3 activation in vivo in bone marrow leukemic cells of a child with newly diagnosed ALL, after treatment with a single dose of VCR. We hypothesized that VCR-induced apoptosis in ALL cells proceeds by a mitochondrial controlled pathway. We further studied the route of VCR-induced apoptosis in Jurkat ALL cells," wrote E. Groninger and colleagues, Beatrix Children's...

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Source: Cancer Weekly (2003-02-04)

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