Brain Tumors

Cure probability less sensitive to infusion duration, drug specificity changes

Published in Cancer Weekly, February 11th, 2003

According to a study from the United States, "Motivated by the recent development of highly specific agents for brain tumors, we develop a mathematical model of the spatio-temporal dynamics of a brain tumor that receives an infusion of a highly specific cytotoxic agent (e.g. IL-4-PE, a cytotoxin comprised of IL-4 and a mutated form of Pseudomonas exotoxin).

"We derive an approximate but accurate mathematical formula for the tumor cure probability in terms of the tumor characteristics (size at time of detection, proliferation rate, diffusion coefficient), drug design (killing rate, loss rate and convection constants for tumor and tissue), and drug delivery...

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Source: Cancer Weekly (2003-02-11)

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