Published in Cancer Weekly, February 11th, 2003
"Although the precise mechanism underlying HDAC inhibitor-induced cell growth arrest is not fully understood, induction of cell cycle related genes such as p21(cip/waf), is thought to be important," wrote Z.X. Chen and colleagues, GlaxoSmithKline Pharmaceuticals Inc., Department of Vascular Biology.
"Here we showed that in the SW620 human colon cancer cell line, TSA and butyrate induced the...
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