Colon Cancer

GADD45 induction may play role in trichostatin-induced cellular effects

Published in Cancer Weekly, February 11th, 2003

According to recent research from the United States, "Historic deacetylase (HDAC) inhibitors such as trichostatin (TSA) and butyrate have been shown to inhibit cancer cell proliferation, induce apoptosis and regulate the expression of genes involved in cell cycle.

"Although the precise mechanism underlying HDAC inhibitor-induced cell growth arrest is not fully understood, induction of cell cycle related genes such as p21(cip/waf), is thought to be important," wrote Z.X. Chen and colleagues, GlaxoSmithKline Pharmaceuticals Inc., Department of Vascular Biology.

"Here we showed that in the SW620 human colon cancer cell line, TSA and butyrate induced the...

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Source: Cancer Weekly (2003-02-11)

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