Prostate Cancer

Prominin-like protein 2 down-regulation may be related to aggressive phenotype

Published in Cancer Weekly, February 11th, 2003

"More than two dozen androgen-responsive genes were identified from the castrated rat ventral prostate on the basis of their induction by exogenous testosterone," wrote Q.H. Zhang and colleagues, Northwestern University, Feinberg Medical School.

"One of the identified genes encodes a novel 886-amino-acid protein that was named prominin-like protein 2 (PROML2) because it shares 32% identity to prominin and prominin-like protein 1, a family of important plasma membrane proteins with five transmembrane domains. The rat PROML2 gene is expressed abundantly in the glandular epithelial cells of the rat ventral prostate," the researchers report.

"The PROML2...

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Source: Cancer Weekly (2003-02-11)

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