Bladder Cancer
Stratification of cancers possible by quantification of specific transcripts
Published in Cancer Weekly, February 11th, 2003
"This study was designed to characterize the expression profiles of nine bladder cancer cell lines (T24, J82, 5637, HT1376, RT4, SCaBER, TCCSUP, UMUC-3, and HT1197) using cDNA microarrays (8976 genes and expressed sequence tags). Novel targets involved in bladder cancer progression of potential clinical relevance were validated by immunohistochemistry using tissue microarrays of primary bladder tumors (n=193 cases). Hierarchical clustering classified uroepithelial cells based on their histopathogenesis and cell cycle alterations," researchers in the United States report.
"Keratin 10 and caveolin-1 transcripts were more abundant in tumor cells from squamous and...
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Source: Cancer Weekly (2003-02-11)
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