Sarcoma

Tumor cell growth could influence matrix metalloproteinase system

Published in Cancer Weekly, February 18th, 2003

According to a report from Taiwan, "This study was designed to investigate the changes of matrix metalloproteinase (MMP)-2 and MMP-9 in host tissues in response to the growth of tumor cells.

"Zymogram showed that the responses of both MMPs in the host tissues were differential but concurrent. The liver, a prime target of metastases, had profound increases in MMP-2 and -9," stated W.H. Kuo and coauthors, Chung Shan Medical University, Institute of Biochemistry.

"The other usual targets had significant increases in MMP-9. MMP-2 was specifically increased in the spleen. These results indicate that the growth of tumor cells at the primary site could...

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Source: Cancer Weekly (2003-02-18)

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