Bolus therapy of 5-FU creates more RNA incorporation than protracted infusion

"Mechanisms of antitumor action of 5-fluorouracil (5-FU) are presumed to inhibit DNA synthesis and RNA function, and the balance of these mechanisms is presumed to depend on the modalities of administration. On the other hand, variability in 5-FU sensitivity of the tumors is also presumed to depend on the enzymes of 5-FU metabolism (dihydropyrimidine dehydrogenase; DPD, rate limiting enzyme of catabolism) and action target (thymidylate synthase; TS). We studied the effects of modalities of administration and enzyme activities related to metabolism and target of 5-FU on the mechanism of antitumor action in patients with colorectal cancer," wrote S. Matsusaka and colleagues, Sano Hospital,...

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