Lymphoma
Cutaneous form has increased expression of skin-homing chemokine receptor CCR4
Published in Cancer Weekly, February 18th, 2003
According to recent research from the United States, "chemokines are critical molecules in leukocyte trafficking, promoting site specific migration to various tissues. The chemokine receptor CCR4 has recently been associated with skin-homing T cells. In view of the potential importance of CCR4 in skin homing of T cells, we investigated the expression pattern of CCR4 and its ligands TARC/CCL17 and MDC/CCL22 in the peripheral blood and skin of patients with cutaneous T cell lymphoma, a putative malignancy of the skin-homing T cells.
"In this study we analyzed the pattern of coexpression of the skin-homing molecules cutaneous lymphocyte antigen (CLA) and CCR4 in the blood...
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Source: Cancer Weekly (2003-02-18)
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