Myeloma

Increased activation of N-ras and K-ras pools induced by increases in IL-6

Published in Cancer Weekly, February 18th, 2003

According to a study from the United States, "ras is a major signaling molecule activated by interleukin-6. There have been no published reports, however, that specifically examine the kinetics and percentage of ras activation in response to IL-6. Model cell lines were used to study activation of N-ras and K-ras induced by IL-6.

"All of the myeloma cell lines we tested express both N-ras and K-ras, but not H-ras. GTP bound ras was measured and the percentage of the total Ras pool that was activated in response to IL-6 was calculated. IL-6 is able to transiently activate both N and K-ras in the ANBL6 cell tine.

"In addition, increasing concentrations...

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Source: Cancer Weekly (2003-02-18)

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