Neurofibromatosis

Researchers discover how regulating gene is, itself, regulated

Published in Cancer Weekly, February 25th, 2003

Dr. Tyler Jacks of MIT and the Howard Hughes Medical Institute, Karen Cichowski of Brigham and Women's Hospital and Harvard Medical School, and their colleagues have discovered how neurofibromin, a key regulator of the ras oncogene, is, itself, regulated.

This discovery has promising therapeutic implications for the treatment of neurofibromatosis type 1 (NF1), a common hereditary disease that results from mutations in the neurofibromin gene, as well as the approximately 30% of human tumors that have altered Ras activity.

The report is published in the February 15, 2003, issue of Genes & Development.

Neurofibromin is a tumor...

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Source: Cancer Weekly (2003-02-25)

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