Tumor Invasiveness
Pseudopodial motility shown to be regulated by HGF-R/Met tyrosine kinase
Published in Cancer Weekly, February 25th, 2003
"The multiple beta-actin rich pseudopodial protrusions of the invasive variant of Moloney sarcoma virus transformed epithelial MDCK cells (MSV-MDCK-INV) are strongly labeled for phosphotyrosine. Increased tyrosine phosphorylation among a number of proteins was detected in MSV-MDCK-INV cells relative to untransformed and MSV-transformed MDCK cells, especially for the hepatocyte growth factor receptor (HGF-R), otherwise known as c-met proto-oncogene. Cell surface expression of HGF-R was similar in the three cell lines, indicating that HGF-R is constitutively phosphorylated in MSV-MDCK-INV cells," researchers in Canada report.
"Both the tyrosine kinase inhibitor...
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Source: Cancer Weekly (2003-02-25)
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