Human Cancer

WNT1 found to be one of estrogen target genes in human MCF-7 cells

Published in Cancer Weekly, February 25th, 2003

According to recent research from Japan, "WNT family of secreted-type glycoproteins play key roles in carcinogenesis and embryogenesis. We have cloned and characterized human WNT2B/WNT13, WNT3, WNT3A, WNT5B, WNT6, WNT7B, WNT8A, WNT8B, WNT10A, WNT10B, WNT11, WNT14 and WNT14B/WNT15 using bioinformatics and cDNA-PCR, and also reported frequent up-regulation of WNT2 in primary gastric cancer.

"Here, expression and regulation of WNT1 in human cancer were investigated using cDNA-PCR," wrote M. Katoh and colleagues, National Cancer Center, Research Institute.

"WNT1 mRNA was relatively highly expressed in OKAJIMA cells (gastric cancer) and BxPC-3 cells...

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Source: Cancer Weekly (2003-02-25)

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