Cancer Weekly

Aging - Gene loss creates age- and gender-dependent cancer syndrome in mice

Breast Cancer - Structure of key receptor determined

Bladder Cancer - Cyclooxygenase inhibitor shows additive effect against urological malignancy

Cancer Therapy - Deacetylase inhibitor FK228 suppresses hypoxia induced activity

Hepatoma - Peroxisome proliferator fenofibrate inhibits growth of human hepatoma cells

Malignant Gliomas - CXCRA is a major chemokine receptor and mediates survival

Pulmonology - Cell density determines extent of damage caused by cigarette smoke exposure

Acute Lymphoblastic Leukemia - Quality of life and psychosocial burden should be seen as clinical problem

Acute Promyelocytic Leukemia - Real-time multiplex RT-PCR useful for t(15;17) analysis

Adenocarcinoma - Polyps linked with colorectal carcinoma via microsatellite instability pathway

Adenocarcinoma - Spectrum broadens as cases reveal previously undescribed mucinous subtype

Aging - RNA degradation by hPNPase(')(Old-35) is common maintenance factor

Anticarcinogenesis - Capsaicin induces ras-transformed cell apoptosis by upregulating JNK-1 and MAPK

Antitumor Activity - Use of soluble B7RP-1-Fc may have value in generating, enhancing activity

Antitumor Response - Natural killer cells with IL-18 receptors respond effectively to IL-18

Brain Cancer - Transforming growth factor-beta a potential target for treating brain tumors

Brain Tumor Edema - Ischemic cause is suggested by brain oxygen pressure values obtained in surgery

Brain Tumors - Tumor grading from magnetic resonance spectroscopy

Breast Cancer - Correlation of core biopsies, therapeutic excisions high in higher grade disease

Breast Cancer - Degradation of ER-alpha by TGF-beta 1 could control tumor growth

Breast Cancer - Fulvestrant submitted for approval in Europe

Breast Cancer - Immunohistochemical distinction of invasive from noninvasive breast lesions

Breast Cancer - Mutation in BRCA2 compromises the interaction with replication protein A

Breast Cancer - Protein is overexpressed in endothelial cells of mouse breast tumor vessels

Breast Cancer - Relief for radiation therapy sought on the grapevine

Breast Cancer - System detects fluorescent compounds in diagnostic process

Breast Cancer Therapy - Foreign DNA prevents mammary adenocarcinoma in transgenic mice

CNS Lymphoma - Molecular genetic diagnosis of a primary central nervous system T cell disease

Cancer Chemotherapy - FDA grants Fast Track designation for investigational oral mucositis drug

Cancer Deaths - Calculating expected number by looking at chances of getting, dying of disease

Cancer Development - Taking the study of cancer cell survival to a new dimension

Cancer Gene Therapy - Patent issued for cancer therapeutic focuses on DNA core of drug

Cancer Metastasis - Domain of matrix metalloproteinase 9 domain demonstrates novel properties

Cancer Risk Factors - Rheumatic syndromes are associated with malignancy

Cancer Therapies - Company increases focus on cancer, eliminates broad-based gene therapy research

Cancer Therapy - Antiangiogenesis antibody, 2C3, shown to inhibit tumor growth by 75%

Cancer Therapy - Ganglioside GD3 acts on mitochondria to protect from hepatoma resistance

Cancer Therapy - MR-controlled hyperthermia demonstrated successful local control of tumor

Cancer Therapy - New drug targets cancer cells

Cancer Therapy - Second phase I trial of VNP40101M in solid tumors begun

Carcinogens - Safety group links playground equipment to cancers

Cell Biology - Gene discovered by Temple researchers found to be multifunctional

Cell Biology - Notch-1 induction required for growth of SV40-transformed mesothelial cells

Cell Death - TNF-alpha-stimulated neutrophil death can increase with caspase inhibition

Cell Lines - Abl kinase inhibitor induces differentiation of v-Abl-transformed pre-B cells

Cellular Transformation - Induction of apoptosis-modulating p202 occurs, contributing to cell survival

Cervical Cancer - Papillomavirus' E6 and E7 proteins differentially protect from cell apoptosis

Cervical Neoplasia - A variation of the Bethesda system could be used in diagnostics

Cervical Neoplasia - Bethesda and other grading terminology should remain in the interim

Colon Cancer - Family history doesn't predict genes, behavior

Colorectal Cancer - Cox-2 inhibitor rofecoxib limits metastatic potential of colorectal carcinoma

Electromagnetic Fields - Highlights of the nonionizing field

Endocrinology - Estrogen modulation of growth factor not controlled through classic pathway

Endometrial Adenocarcinoma - Estrogen can stimulate an ERE-driven gene to promote DNA synthesis

Environmental Toxins - Fallout from nuclear tests killed 11,000, CDC concludes

Epstein-Barr Virus - Lytic reactivation in infected B cells selectively arrests host functions

Erythroleukemia - TEL accelerates differentiation of cells

Ewing Sarcoma - The oncogenic protein Id2 is upregulated by EWS/ets protein and c-myc

Friend Erythroleukemia - PKC pathway involved in survival response to ionizing radiation of cell line

Gastric Cancer - Pathogenicity of Helicobacter pylori may not be determined by cag PAI genes

Gene Vectors - Herpes simplex virus protein VP22 a promising tool for gene delivery

Glioblastoma - Genetic events a hallmark of angiogenesis in astrocytomas

Glioma - Combination of antibody and nimustine deconstruct glioblastoma xenografts

HTLV-1 Infection - Resistance to syncytia is due to viral protein's truncation

Helicobacter Pylori - Two methylase genes, hpyIIIM and hpyIM, are preceded by alternative genes

Hematopoietic Tumors - Apoptosis is induced by treatment with a new bisphosphonate, YM529

Hematopoietic Tumors - Method of mapping integration sites identifies new CISs

Hepatic Fibrosis - Activated stellate cells express TRAIL and can be eliminated differentially

Hodgkin Disease - NOVP chemotherapy induces sperm aneuploidies

Hodgkin Lymphoma - Cell lines characterized by frequent aberrations on chromosomes 2p, 9p