Hematopoietic Tumors

Apoptosis is induced by treatment with a new bisphosphonate, YM529

Published in Cancer Weekly, March 4th, 2003

According to a study from Japan, "In recent years, it has been reported that bisphosphonates inhibited the cell cycle of myeloma cells to inhibit cell proliferation directly, and it was also reported that bisphosphonates induced apoptosis of myeloma cells in vitro. Recently, YM529 was developed as a new, third generation bisphosphonate. In our experiment, we investigated whether YM529 showed an antitumor effect on hematopoietic tumor cell lines other than myeloma, and we compared YM529 with YM175, which had a relatively more potent antitumor effect than that of existing bisphosphonates.

"We found that YM529 inhibited cell proliferation in various hematopoietic tumor...

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Source: Cancer Weekly (2003-03-04)

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