Hematopoietic Tumors

Method of mapping integration sites identifies new CISs

Published in Cancer Weekly, March 4th, 2003

"Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a powerful cancer gene discovery tool," researchers in the United States report.

"Here, we describe a high-throughput, single nucleotide polymorphism (SNP)-based method, for mapping retroviral integration sites cloned from mouse tumors, and a bacterial artificial chromosome (BAC) hybridization method, for localizing these retroviral integration sites to common sites of retroviral integration (CISs).

"Several new CISs were identified, including one CIS that mapped near Notch1, a gene that has been causally associated with human T-cell tumors," wrote H.F. Shen and colleagues,...

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Source: Cancer Weekly (2003-03-04)

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