Leukemia

Sildenafil and vardenafil induce caspase-dependent apoptosis

Published in Cancer Weekly, March 4th, 2003

According to a study from France, "Type 4 phosphodiesterase (PDE4) inhibitors reportedly induce apoptosis in chronic lymphocytic leukemia (CLL) cells.

"Following clinical improvement of one previously untreated CLL patient with sildenafil therapy, we evaluated the in vitro induction of apoptosis in CLL cells by 4 PDE5/6 inhibitors, including sildenafil, vardenafil, zaprinast, and methoxyquinazoline (MQZ)," stated M. Sarfati and coauthors, Paris.

"After 24 hours of culture, the various PDE inhibitors differed in their ability to induce apoptosis, with zaprinast displaying no killing effect. Normal B cells isolated from control donors were totally...

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Source: Cancer Weekly (2003-03-04)

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