Ovarian Cancer

The CD40 receptor can be useful target for cancer gene therapies

Published in Cancer Weekly, March 11th, 2003

by Sonia Nichols, senior medical writer - Medical researchers believe CD40 would be an excellent candidate receptor for adenovirus-mediated gene therapies targeting cancer in the ovaries and other areas of the body.

Many tumor cells do not express the coxsackie and adenovirus receptor (CAR), for which adenoviruses show a natural affinity. As a result, scientists have explored other cellular components for their ability to foster adenovirus infection.

Researchers at the University of Kuopio in Finland and the University of Alabama in Birmingham now say that CD40 could be an important molecule for adenovirus-mediated delivery of gene therapy to...

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Source: Cancer Weekly (2003-03-11)

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