Cancer Chemotherapy

P-glycoprotein-mediated multidrug resistance can be blocked by ginsenoside Rg3

Published in Cancer Weekly, March 11th, 2003

P-glycoprotein-mediated multidrug resistance can be blocked by ginsenoside Rg3.

According to a study from South Korea, "Multidrug resistance has been a major problem in cancer chemotherapy. In this study, in vitro and in vivo modulations of MDR by ginsenoside Rg3, a red ginseng saponin, were investigated. In flow cytometric analysis using rhodamine 123 as an artificial substrate, Rg3 promoted accumulation of rhodamine 123 in drug resistant KBV20C cells in a dose dependent manner, but it had no effect on parental KB cells.

"Additionally, Rg3 inhibited [H³]vinblastine efflux and reversed MDR to doxorubicin, COL, VCR, and VP-16 in KBV20C...

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Source: Cancer Weekly (2003-03-11)

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