Malignant Mesothelioma
TGF-beta inhibits interferon-gamma synthesis by anti-PPD CD4(+) T-cell clone
Published in Cancer Weekly, March 18th, 2003
According to recent research from Italy, "Besides acting complexly on both normal and tumor cells, transforming growth factor-B (TGF-B) can determine the nature of the response to the antigen, strongly inhibiting the differentiation of naive CD4(+) T-cells toward a T helper-1 (Th-1) phenotype; in a number of experimental models, TGF-B also appeared to be a potent immunosuppressant factor.
"TGF-B was shown to be released by some human malignant mesothelioma (MMe) cells, which affects the immune response to this tumor.
"Thus, for a better understanding of...
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Source: Cancer Weekly (2003-03-18)
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