Immediate and sustained release doses performed similarly during titration

"A titration procedure using immediate-release morphine given 4 times hourly is recommended during start of oral morphine for cancer pain. This recommendation is not based on evidence from controlled studies, and many physicians start morphine treatment with controlled-release morphine. We included 40 patients with malignant disease and pain despite treatment with opioids for mild to moderate pain in a randomized, double blind, double dummy, parallel group study comparing titration with immediate-release morphine given 4 times hourly with titration, with sustained-release morphine given once...

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