Oncology
A macrophage activating factor inhibits angiogenesis and tumor growth in mice
Published in Cancer Weekly, March 25th, 2003
"We have isolated a selectively deglycosylated form of vitamin D binding protein-macrophage activating factor (DBP-maf) generated from systemically available DBP by a human pancreatic cancer cell line. DBP-maf is anti proliferative for endothelial cells and antiangiogenic in the chorioallantoic membrane assay," researchers in the United States report.
"DBP-maf administered daily was able to potently inhibit the growth of human pancreatic cancer in immune compromised mice (T/C=0.09). At higher doses, DBP-maf caused tumor regression. Histological examination revealed that...
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Source: Cancer Weekly (2003-03-25)
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