Pancreatic Cancer

MUC2 and MUC5AC mucins produced only in cancer are regulated differently

Published in Cancer Weekly, March 25th, 2003

MUC2 and MUC5AC mucins produced only in cancer are regulated differently.

According to recent research from the United States, "Anomalous expression of certain types of mucins occurs in pancreatic tumors, but little is known about the causes. MUC2 and MUC5AC are not expressed in normal pancreas.

"In the present study, an immunohistochemical screening showed that MUC2 antigen was expressed in 6% of invasive tumors. Of the pancreatic cell lines, 2.4% expressed MUC2 message and antigen.

"In contrast, MUC5AC antigen was expressed in 86-100% of invasive adenocarcinoma (depending on the antibody). MUC5AC message and antigen were...

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Source: Cancer Weekly (2003-03-25)

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