Pediatric Leukemia

High-dose methylprednisolone increased many peripheral blood lymphocyte subsets

Published in Cancer Weekly, March 25th, 2003

High-dose methylprednisolone increased many peripheral blood lymphocyte subsets.

A previous study from Turkey "had demonstrated a favorable effect of high-dose steroid in the treatment of children with acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML). This study was performed to determine the effect of short-course high-dose methylprednisolone (HDMP) treatment on the peripheral blood (PB) T lymphocyte subsets, and blast cells, during remission induction treatment in 23 children with newly diagnosed acute leukemia (16 with ALL, seven with AML). All patients were administered HDMP as a single daily oral dose of 30 mg/kg for the first 4 days of...

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Source: Cancer Weekly (2003-03-25)

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