Proteomics
RING finger ubiquitin protein ligases have implications for tumorigenesis
Published in Cancer Weekly, March 25th, 2003
"Covalent modification of proteins with ubiquitin regulates almost all aspects of eukaryotic cellular function," researchers in the United States report.
"Ubiquitin protein ligases (E3s) play central regulatory roles in that they provide substrate specificity to this process and, therefore, represent attractive molecular targets for disease therapy," wrote S. Fang and colleagues, National Cancer Institute.
"We summarize recent advances in our understanding of RING finger and RING finger-related E3s with emphasis on BRCA1 and the tumor autocrine motility...
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Source: Cancer Weekly (2003-03-25)
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