Breast Cancer

Mechanism of ginsenoside Rc and Re stimulation of c-fos expression studied

Published in Cancer Weekly, March 25th, 2003

Researchers in South Korea are studying how ginsenoside Rc and Re induce c-fos expression in MCF-7 human breast carcinoma cells.

Y.J. Lee and coworkers at Sejong University said they had "found that ginsenoside Rc and Re induce c-fos in MCF-7 human breast carcinoma cells at both the mRNA and protein levels. However, neither ginsenoside activated the expression of reporter gene under the control of AP-1/TPA response elements."

They said they'd also looked at "the possibility that ginsenoside Rc and Re act by binding to intracellular steroid hormone receptors that act as transcriptional factors in the nucleus in inducing c-fos mRNA in MCF7 human...

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Source: Cancer Weekly (2003-03-25)

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