Published in Cancer Weekly, April 1st, 2003
According to a study from Canada, "Thromboembolic disorders are common in cancer patients. Two major contributing factors are central venous catheters for drug delivery and the use of l-aparaginase, which decreases the plasma antithrombin level, but the causes of the hypercoagulable state in these patients are not fully understood. In this study, the T24/83 cell line was used as a model to investigate the effects of chemotherapeutic agents on cell surface thrombin regulation.
"Plasma thrombin generation and prothrombin consumption was increased in most of the treated...
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