Susan Hasty, Publisher
Table of Contents . . . April 8th, 2003
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Cancer Weekly | Other Publications
Cancer Therapy - Researchers discover new method to treat cancer
Liver Cancer - Metastasis gene may be useful for diagnosis and treatment
Biomarkers - Several genes may be reliable markers for primary liver cancer
Breast Cancer - The tumor suppressor maspin inhibits angiogenesis in breast malignancies
Cancer Screening - Hispanic women in border states less likely to receive screening for breast, cervical cancers
Lung Cancer - Treatment improves with better timing
Abdominal Masses - Researchers present guide to evaluation and diagnosis of masses
Antiangiogenesis - Somatostatin is a potent inhibitor of angiogenesis and cancer
Anticancer Agent - Indisulam, an anticancer sulfonamide, is in clinical development
Anticancer Effect - Sodium salicylate induces ROS production and subsequent apoptosis
Antitumor Cytotoxity - CD57-T and CD56-T are different populations but DP-T cells originate from both
Bladder Cancer - Some CDKN2A gene polymorphisms in the population lower cancer survival
Brain Cancer - Melanoma and renal carcinoma metastases have higher blood volume than others
Brain Imaging - Spectroscopy can now map structure with corresponding metabolic activity
Brain Metastases - Recent advances lead to significant improvements in prognosis
Brain Tumor - Case reports: Long-term survivors of neurocristopathy-associated neuroblastoma
Brain Tumor - Malignant astrocytoma occurs 10 years after treatment of craniopharyngioma
Brain Tumor - Primitive neuroectodermal may represent an unknown paraneoplastic syndrome
Brain Tumors - Chromosomal imbalances are rare in craniopharyngiomas
Breast Cancer - Estrogen influences vascular endothelial growth factor in a biphasic manner
Breast Cancer - Histological examination is necessary to diagnose phyllodes breast tumors
Breast Cancer - Lack of physical activity may affect outcome of patients
Breast Cancer - Molecular screening discovers thousands of new genes, including BASE
Breast Cancer - Researchers study mother-child relationships within the cancer experience
Breast Cancer - Serum antibodies to lipophilin B are correlated to disease stage
Breast Cancer - Women's fears of recurrence measured
Breast Cancer Metastasis - Cerivastatin quells molecular mechanisms that cause breast cancer aggression
Breast Cancer Screening - Cancer history, insurance predict future mammograms
Breast Cancer Screening - Frequent follow-up for 'probably benign' mammograms questioned
Burkitt Lymphoma - Gamma irradiation induces Epstein-Barr virus reactivation
Burkitt Lymphoma - Mofarotene is effective alone or in combination with 2-methoxyestradiol
Cancer Biomarkers - Angiogenesis relates to recurrence in women with breast cancer
Cancer Development - SPARC highlights the importance of cell-matrix interactions in tumorigenicity
Cancer Diagnosis - Cancer has causal role in seven vascular disorders preceding cancer diagnosis
Cancer Gene Therapy - E1A sensitizes cells to TNF alpha by downregulating c-FLIP gene
Cancer Prevention - New York-Presbyterian launches new front in war on cancer
Cancer Staging - Thoracoscopic sentinel node biopsy useful in internal mammary node staging
Cancer Therapies - Patent obtained for unique form of vitamin D
Cancer Therapy - Companies announce agreement to market Novantrone
Cancer Therapy - Interleukin-12 gene therapy is a viable alternative for treating thyroid cancer
Cancer Therapy - Thrombospondins show promise as antiangiogenic therapies
Cancer Vaccine - CD4+CD25+ lymphocytes play role in immune response to melanoma antigens
Cancer Vaccine - HPV16-associated, MHC class I+ tumors more susceptible than class I- to therapy
Cancer Vaccine - Immature dendritic cell vaccine causes immune response against melanoma
Cancer Vaccine - Rapid generation of antigen-presenting cells from leukemic blasts developed
Carcinosarcoma - Gastric carcinosarcoma may progress from conventional tubular adenocarcinoma
Cerebellar Tumor - Large-cell medulloblastoma may have arrestin-like protein expression
Cervical Cancer - A new technique of laparoscopic hysterectomy may be useful in cervical cancer
Cervical Cancer - Interleukin-6 promotes gynecological malignancy by activating angiogenesis
Cervical Cancer - Local interleukin-2 therapy inhibits proliferation of HPV-associated tumor
Cervical Cancer - The E2/E6 gene ratio in papillomavirus-16 cancer can help diagnose stage
Chemotherapy - Cancer patient care can be cost-effectively improved by simple nursing changes
Chronic Myelogenous Leukemia - Imatinib mesylate treatment feasible for heavily pretreated patients
Chronic Myeloid Leukemia - Gleevec is superior to traditional drug therapy for patients newly diagnosed CML
Colon Cancer - Cisplatin resistance could be defeated with gene targeting
Colon Cancer - Low dietary copper increases risk with free radical production and AP activity
Colon Cancer - NCI awards grant for human clinical trial of NCX 4016
Colorectal Cancer - Cancer survivors deliver screening message to Pennsylvania legislators
Colorectal Cancer - Family history may be useful in determining colorectal cancer risk
Colorectal Cancer - Mechanism of liganded-VDR-induction of CYP3A4 investigated
Colorectal Cancer - The human DNA methyltransferase gene DNMT1 is a target for cancer therapy
Colorectal Cancer - Two expressed enzyme levels can predict the efficacy of chemotherapy
Congenital Leukemia - Prenatal presentation supports the in utero development of congenital leukemia
DNA Research - Researchers synthesize CC-1065 analogues
Dendritic Cell Vaccine - Pancreatic cancer patient successfully treated with dendritic cell vaccine
Diabetes Survival and Mortality - Diabetes significantly increases mortality and recurrence rates in colon cancer patients
Diet and Nutrition - Delphinidin suppresses mechanisms linked to cancer metastasis and heart disease
Dietary Anticarcinogens - Selected nutrient intake from food still substandard in Linxian, China
Differential Cytotoxicity - Alpha-lipoic acid requires p27(Kip) for apoptosis of tumor cell lines
Doppler Imaging - Doppler waveform analysis is useful in diagnosing cervical lymphadenopathy
Drug Determination - Method presented for quantifying paclitaxel in plasma
Drug Discovery - Several experiments prove principle of genetically engineered mouse models
Endometrial Cancer - RU486 inhibits growth of cells by involving the NF-kappa B signaling pathway
Endometrial Carcinoma - The new human cell line EN has a TP53 mutation and a 1-day doubling time
Epithelial Ovarian Cancer - Researchers develop first mouse model
Epstein-Barr Virus - EBV not shown to be associated with breast and hepatocellular carcinoma
Ewing Sarcoma - Identification of molecular abnormalities may improve patient survival
Eye Pain/Paralysis - Tolosa-Hunt syndrome could be diagnosed instead of cancers without cranial MRI
Fibroma - Surgeons remove a cementifying fibroma from the ethmoidal sinus and cranial base
Finance - $40M line of credit established with for Genasense program
Gallbladder Cancer - Transforming growth factor beta is a strong biomarker in gallbladder cancer
Gastroenterology - COX-2 inhibitors could suppress atypical growth in a pancreatic - liver disorder
Genetic Replication - Telomeres have allelic length variation and can shorten slowly or quickly
HIV/AIDS Pathogenesis - Arsenic trioxide enhances reverse transcription, blocks Ref1 antiviral activity
Head and Neck Cancer - A combination of thermoradiotherapy and suicide genes eradicates cancer cells
Head and Neck Cancer - Laser Doppler fluxmetry readings improve laryngeal cancer blood flow analysis
Hematology - Advances led to prospects for targeted therapy in hematological malignancies
Hematology - Angiogenesis may play a role in the pathogenesis of hairy cell leukemia
Hematology - Good prospects reported for Aplidin in leukemia, lymphoma
Hepatocellular Carcinoma - Cadmium inhibits spontaneous liver cancer formation in some animal models
Hepatocellular Carcinoma - Metastasis gene may be useful for diagnosis and treatment of liver cancer
Human Rhabdomyosarcoma - Actin isoform expression can be used to diagnose, subtype
Immunology - 4-1BB ligand costimulates CD28-negative T cells
Infrared Spectroscopy - Fourier-transform infrared spectroscopy can be used to monitor apoptosis
Kidney Cancer - Patients enrolled in kidney cancer vaccine clinical trial
Leukemia - A rare leukemia type has certain genetic mutation and symptom characteristics
Leukemia - Inherited neurofibromatosis type 1 leads to juvenile myelomonocytic leukemia
Leukemia - Mercuric chloride induces apoptosis through mitochondrial-dependent pathway
Leukemia Cells - Distamycin and nitrogen mustard conjugates synthesized
Lewis Lung Cancer - An aqueous extract of Phyllanthus urinaria has cancer specific cytotoxicity
Liver Cancer - Metastasis from neuroendocrine tumors can be treated with doxorubicin TACE
Liver Cancer - Natural lymphoblastoid alpha interferon prevents liver cancer
Lung Cancer - Nonsteroidal anti-inflammatory drugs may protect smokers
Lung Cancer - Quality-of-life data contribute to our understanding of patients' experiences
Lung Cancer - Researchers study radiation-induced lung cancer in Hodgkin disease patients
Lung Cancer - Researchers testing new drug combination
Lung Cancer - Results of Affinitak phase III trial in non-small cell lung cancer released
Lung Cancer - Study finds risk for lung cancer varies among smokers
Lung Cancer - Two colliding cancers - adenosquamous and neuroendocrine origin - found
Lymphoma - Brain lesions may be diagnosed from angiomas as intravascular B cell lymphoma
Malignant Rhabdoid Tumor - INI1 expression after adenovirus delivery induces cell cycle arrest
Melanocytic Tumors - Comparative genomic hybridization can help classify ambiguous lesions
Metastasis - The heparanase promoter can be transactivated by ETS transcription factors
Mitochondrial Cytochromes - NF-kappa B is found in the mitochondria, where it downregulates gene expression
Mixed Tumor - Case report: Unusual, mixed tumor in deep soft tissue of the leg
Mucinous Adenocarcinoma - An ovarian teratoma undergoes malignant transformation
Multiple Myeloma - Molecular stem cell graft contamination tests fail to predict outcome
Multiple Myeloma - The nitric oxide synthase inhibitor L-NAME stalls angiogenesis in plasmacytoma
Mycochemotherapy - A component of Isaria japonica induces apoptosis in leukemia cells
Myeloma Treatment - Novel retinoid AHPN/CD437 induces rapid but incomplete apoptotic response
Myofibroblastic Tumor - Malignant transformation is treated successfully by surgery and chemotherapy
Neovascularization - The nitric oxide pathway is a feasible target for controlling angiogenesis
Neuroblastoma - E2F proteins regulate MYCN expression in neuroblastomas
Neuroblastomas - CHD5 is a nervous system chromodomain protein found absent in the cancer
Neuroscience - Anti-MIF technology licensed to large pharmaceutical company
Nicotine Addiction - Cigarette smoking may cause a less sensitive cough reflex in men
Nutritional Therapy - Folate deficiency and related disease risk can be easily prevented
Obesity Risk Factor - Hypothalamus damage increases risk of intractable obesity in children with brain tumors
Oncogene Function - C-myc has many molecular interactions with cell cycle and growth arrest genes
Oncogenesis - Apoptosis and senescence counteract oncogenic transformation
Oncogenesis - Hepatitis C virus core protein may play a role in malignant lymphoma formation
Oncology - Anthracycline antibiotics target neovascularization and other functions
Oncology - Manganese superoxide dismutase causes cells to resist doxorubicin therapy
Oncology - Vascular endothelial growth factor modulates the migration of breast cancer
Ophthalmology - Drug-induced eye inflammation can cause vision loss if not caught early enough
Orthopedic Oncology - Researchers report the remission of an epithelioid hemangioma of bone
Osteosarcoma - Case report: Postradiation osteosarcoma after latency period of 3 years
Ovarian Cancer - Modified coxsackie-adenovirus receptor increases adenoviral transgene expression
Ovarian Cancer - Synergistic effects were achieved by Apo2L/TRAIL and cisplatin combination
Ovarian Tumor - Case report: 10-year-old girl presents with rare sclerosing stromal tumor of the ovary
Oxidative Stress - A new method measures oxidation products like oxysterols and alpha-tocopherol
Pancreatic Cancer - Multislice spiral CT can give diagnostic detail and determine resectability
Parathyroid Cancer - Molecular markers, Ki-67 and p27, may distinguish carcinoma from adenoma
Patient Care - Cancer patients and their relatives disagree on the quality of support
Pediatric Cancer - Promising approaches are being tested in pediatric cancer
Pelvic Sarcoma - Some pelvic sarcoma types have a high sacroiliac infiltration risk
Phytomedicine - Dehydrocrotonin from Croton cajucara is cytotoxic to leukemia cells
Pituitary Tumor - Histological differences between pituicytoma and pilocytic astrocytoma outlined
Plant Antioxidant - Rhoeo discolor extract is not genotoxic or mutagenic, but is antioxidant
Primary Melanoma - C-myc oncoprotein is a prognostic marker for intermediate-thickness melanoma
Prostate Cancer - Screening for prostate cancer
Prostate Epithelial Cells - Whey protein treatment increases glutathione, thus protects against oxidants
Public Water Disinfection - The toxicology of drinking water disinfection byproducts is to be assessed
Quality of Life - Hope was not altered by knowledge of disease status or pain in cancer patients
Quality of Life - Researchers measure quality of palliative care in surviving family members
Radiation Delivery - Gamma Knife Center treats 1000th patient
Retinoblastoma - Two products of Ink4a-Arf regulate retinoblastoma protein
Rhabdomyosarcoma - Gene that drives apoptosis also plays key role in development of skeletal muscle
Solid Tumors - Cyclin A1 is expressed at different levels in many tumors
Squamous Cell Carcinoma - Helicobacter pylori infection may be a risk for malignancy in head and neck
Squamous Cell Carcinoma - Inhibition of caspase-9 and Apaf-1 function may occur in cisplatin resistance
Squamous Lung Cancer - Magnolol has antiproliferative and antiapoptotic effects in a cell line
TGF-Beta Resistance - Downregulation of Smad3 leads to resistance to TGF-beta-induced growth arrest
Terminal Cancer - Survival estimates are accurate and linked symptomatically to peripheral edema
Thermotherapy - Monte Carlo simulation aids treatment planning, monitoring
Thyroid Cancer - An adenovirus encoding for rat protein suppresses human thyroid carcinoma
Thyroid Cancer - Cip-1 presence enhances apoptosis induced by manumycin and paclitaxel
Thyroid Carcinoma - Tumor histological subtypes have different Ret chimeric transcripts
Thyroid Liposarcoma - Case report: Liposarcoma of the thyroid gland
Toxicity - Probability of toxicity estimated in phase I trials
Trichosporon Asahii - Voriconazole is successful in treating a patient with acute myeloid leukemia
Tumor Targets - Some heparin derivatives are angiostatic
Tumorigenesis - Selective inhibitors of COX-2 may be effective in preventing and treating cancer
Urology - Adenoviral-mediated retinoblastoma 94 localizes to bladder cancer cells
Urology - Piroxicam and chemotherapy combine to diminish urinary bladder cancer
Urothelial Neoplasms - Controversies exist in classification and grading of urothelial neoplasms
Vertebral Metastases - Predicting risk of fracture and epidural impingement may help patient management
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