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Cancer Weekly

Susan Hasty, Publisher

Table of Contents . . . April 8th, 2003

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Cancer Weekly | Other Publications

Cancer Therapy - Researchers discover new method to treat cancer

Liver Cancer - Metastasis gene may be useful for diagnosis and treatment

Biomarkers - Several genes may be reliable markers for primary liver cancer

Breast Cancer - The tumor suppressor maspin inhibits angiogenesis in breast malignancies

Cancer Screening - Hispanic women in border states less likely to receive screening for breast, cervical cancers

Lung Cancer - Treatment improves with better timing

Abdominal Masses - Researchers present guide to evaluation and diagnosis of masses

Antiangiogenesis - Somatostatin is a potent inhibitor of angiogenesis and cancer

Anticancer Agent - Indisulam, an anticancer sulfonamide, is in clinical development

Anticancer Effect - Sodium salicylate induces ROS production and subsequent apoptosis

Antitumor Cytotoxity - CD57-T and CD56-T are different populations but DP-T cells originate from both

Bladder Cancer - Some CDKN2A gene polymorphisms in the population lower cancer survival

Brain Cancer - Melanoma and renal carcinoma metastases have higher blood volume than others

Brain Imaging - Spectroscopy can now map structure with corresponding metabolic activity

Brain Metastases - Recent advances lead to significant improvements in prognosis

Brain Tumor - Case reports: Long-term survivors of neurocristopathy-associated neuroblastoma

Brain Tumor - Malignant astrocytoma occurs 10 years after treatment of craniopharyngioma

Brain Tumor - Primitive neuroectodermal may represent an unknown paraneoplastic syndrome

Brain Tumors - Chromosomal imbalances are rare in craniopharyngiomas

Breast Cancer - Estrogen influences vascular endothelial growth factor in a biphasic manner

Breast Cancer - Histological examination is necessary to diagnose phyllodes breast tumors

Breast Cancer - Lack of physical activity may affect outcome of patients

Breast Cancer - Molecular screening discovers thousands of new genes, including BASE

Breast Cancer - Researchers study mother-child relationships within the cancer experience

Breast Cancer - Serum antibodies to lipophilin B are correlated to disease stage

Breast Cancer - Women's fears of recurrence measured

Breast Cancer Metastasis - Cerivastatin quells molecular mechanisms that cause breast cancer aggression

Breast Cancer Screening - Cancer history, insurance predict future mammograms

Breast Cancer Screening - Frequent follow-up for 'probably benign' mammograms questioned

Burkitt Lymphoma - Gamma irradiation induces Epstein-Barr virus reactivation

Burkitt Lymphoma - Mofarotene is effective alone or in combination with 2-methoxyestradiol

Cancer Biomarkers - Angiogenesis relates to recurrence in women with breast cancer

Cancer Development - SPARC highlights the importance of cell-matrix interactions in tumorigenicity

Cancer Diagnosis - Cancer has causal role in seven vascular disorders preceding cancer diagnosis

Cancer Gene Therapy - E1A sensitizes cells to TNF alpha by downregulating c-FLIP gene

Cancer Prevention - New York-Presbyterian launches new front in war on cancer

Cancer Staging - Thoracoscopic sentinel node biopsy useful in internal mammary node staging

Cancer Therapies - Patent obtained for unique form of vitamin D

Cancer Therapy - Companies announce agreement to market Novantrone

Cancer Therapy - Interleukin-12 gene therapy is a viable alternative for treating thyroid cancer

Cancer Therapy - Thrombospondins show promise as antiangiogenic therapies

Cancer Vaccine - CD4+CD25+ lymphocytes play role in immune response to melanoma antigens

Cancer Vaccine - HPV16-associated, MHC class I+ tumors more susceptible than class I- to therapy

Cancer Vaccine - Immature dendritic cell vaccine causes immune response against melanoma

Cancer Vaccine - Rapid generation of antigen-presenting cells from leukemic blasts developed

Carcinosarcoma - Gastric carcinosarcoma may progress from conventional tubular adenocarcinoma

Cerebellar Tumor - Large-cell medulloblastoma may have arrestin-like protein expression

Cervical Cancer - A new technique of laparoscopic hysterectomy may be useful in cervical cancer

Cervical Cancer - Interleukin-6 promotes gynecological malignancy by activating angiogenesis

Cervical Cancer - Local interleukin-2 therapy inhibits proliferation of HPV-associated tumor

Cervical Cancer - The E2/E6 gene ratio in papillomavirus-16 cancer can help diagnose stage

Chemotherapy - Cancer patient care can be cost-effectively improved by simple nursing changes

Chronic Myelogenous Leukemia - Imatinib mesylate treatment feasible for heavily pretreated patients

Chronic Myeloid Leukemia - Gleevec is superior to traditional drug therapy for patients newly diagnosed CML

Colon Cancer - Cisplatin resistance could be defeated with gene targeting

Colon Cancer - Low dietary copper increases risk with free radical production and AP activity

Colon Cancer - NCI awards grant for human clinical trial of NCX 4016

Colorectal Cancer - Cancer survivors deliver screening message to Pennsylvania legislators

Colorectal Cancer - Family history may be useful in determining colorectal cancer risk

Colorectal Cancer - Mechanism of liganded-VDR-induction of CYP3A4 investigated

Colorectal Cancer - The human DNA methyltransferase gene DNMT1 is a target for cancer therapy

Colorectal Cancer - Two expressed enzyme levels can predict the efficacy of chemotherapy

Congenital Leukemia - Prenatal presentation supports the in utero development of congenital leukemia

DNA Research - Researchers synthesize CC-1065 analogues

Dendritic Cell Vaccine - Pancreatic cancer patient successfully treated with dendritic cell vaccine

Diabetes Survival and Mortality - Diabetes significantly increases mortality and recurrence rates in colon cancer patients

Diet and Nutrition - Delphinidin suppresses mechanisms linked to cancer metastasis and heart disease

Dietary Anticarcinogens - Selected nutrient intake from food still substandard in Linxian, China

Differential Cytotoxicity - Alpha-lipoic acid requires p27(Kip) for apoptosis of tumor cell lines

Doppler Imaging - Doppler waveform analysis is useful in diagnosing cervical lymphadenopathy

Drug Determination - Method presented for quantifying paclitaxel in plasma

Drug Discovery - Several experiments prove principle of genetically engineered mouse models

Endometrial Cancer - RU486 inhibits growth of cells by involving the NF-kappa B signaling pathway

Endometrial Carcinoma - The new human cell line EN has a TP53 mutation and a 1-day doubling time

Epithelial Ovarian Cancer - Researchers develop first mouse model

Epstein-Barr Virus - EBV not shown to be associated with breast and hepatocellular carcinoma

Ewing Sarcoma - Identification of molecular abnormalities may improve patient survival

Eye Pain/Paralysis - Tolosa-Hunt syndrome could be diagnosed instead of cancers without cranial MRI

Fibroma - Surgeons remove a cementifying fibroma from the ethmoidal sinus and cranial base

Finance - $40M line of credit established with for Genasense program

Gallbladder Cancer - Transforming growth factor beta is a strong biomarker in gallbladder cancer

Gastroenterology - COX-2 inhibitors could suppress atypical growth in a pancreatic - liver disorder

Genetic Replication - Telomeres have allelic length variation and can shorten slowly or quickly

HIV/AIDS Pathogenesis - Arsenic trioxide enhances reverse transcription, blocks Ref1 antiviral activity

Head and Neck Cancer - A combination of thermoradiotherapy and suicide genes eradicates cancer cells

Head and Neck Cancer - Laser Doppler fluxmetry readings improve laryngeal cancer blood flow analysis

Hematology - Advances led to prospects for targeted therapy in hematological malignancies

Hematology - Angiogenesis may play a role in the pathogenesis of hairy cell leukemia

Hematology - Good prospects reported for Aplidin in leukemia, lymphoma

Hepatocellular Carcinoma - Cadmium inhibits spontaneous liver cancer formation in some animal models

Hepatocellular Carcinoma - Metastasis gene may be useful for diagnosis and treatment of liver cancer

Human Rhabdomyosarcoma - Actin isoform expression can be used to diagnose, subtype

Immunology - 4-1BB ligand costimulates CD28-negative T cells

Infrared Spectroscopy - Fourier-transform infrared spectroscopy can be used to monitor apoptosis

Kidney Cancer - Patients enrolled in kidney cancer vaccine clinical trial

Leukemia - A rare leukemia type has certain genetic mutation and symptom characteristics

Leukemia - Inherited neurofibromatosis type 1 leads to juvenile myelomonocytic leukemia

Leukemia - Mercuric chloride induces apoptosis through mitochondrial-dependent pathway

Leukemia Cells - Distamycin and nitrogen mustard conjugates synthesized

Lewis Lung Cancer - An aqueous extract of Phyllanthus urinaria has cancer specific cytotoxicity

Liver Cancer - Metastasis from neuroendocrine tumors can be treated with doxorubicin TACE

Liver Cancer - Natural lymphoblastoid alpha interferon prevents liver cancer

Lung Cancer - Nonsteroidal anti-inflammatory drugs may protect smokers

Lung Cancer - Quality-of-life data contribute to our understanding of patients' experiences

Lung Cancer - Researchers study radiation-induced lung cancer in Hodgkin disease patients

Lung Cancer - Researchers testing new drug combination

Lung Cancer - Results of Affinitak phase III trial in non-small cell lung cancer released

Lung Cancer - Study finds risk for lung cancer varies among smokers

Lung Cancer - Two colliding cancers - adenosquamous and neuroendocrine origin - found

Lymphoma - Brain lesions may be diagnosed from angiomas as intravascular B cell lymphoma

Malignant Rhabdoid Tumor - INI1 expression after adenovirus delivery induces cell cycle arrest

Melanocytic Tumors - Comparative genomic hybridization can help classify ambiguous lesions

Metastasis - The heparanase promoter can be transactivated by ETS transcription factors

Mitochondrial Cytochromes - NF-kappa B is found in the mitochondria, where it downregulates gene expression

Mixed Tumor - Case report: Unusual, mixed tumor in deep soft tissue of the leg

Mucinous Adenocarcinoma - An ovarian teratoma undergoes malignant transformation

Multiple Myeloma - Molecular stem cell graft contamination tests fail to predict outcome

Multiple Myeloma - The nitric oxide synthase inhibitor L-NAME stalls angiogenesis in plasmacytoma

Mycochemotherapy - A component of Isaria japonica induces apoptosis in leukemia cells

Myeloma Treatment - Novel retinoid AHPN/CD437 induces rapid but incomplete apoptotic response

Myofibroblastic Tumor - Malignant transformation is treated successfully by surgery and chemotherapy

Neovascularization - The nitric oxide pathway is a feasible target for controlling angiogenesis

Neuroblastoma - E2F proteins regulate MYCN expression in neuroblastomas

Neuroblastomas - CHD5 is a nervous system chromodomain protein found absent in the cancer

Neuroscience - Anti-MIF technology licensed to large pharmaceutical company

Nicotine Addiction - Cigarette smoking may cause a less sensitive cough reflex in men

Nutritional Therapy - Folate deficiency and related disease risk can be easily prevented

Obesity Risk Factor - Hypothalamus damage increases risk of intractable obesity in children with brain tumors

Oncogene Function - C-myc has many molecular interactions with cell cycle and growth arrest genes

Oncogenesis - Apoptosis and senescence counteract oncogenic transformation

Oncogenesis - Hepatitis C virus core protein may play a role in malignant lymphoma formation

Oncology - Anthracycline antibiotics target neovascularization and other functions

Oncology - Manganese superoxide dismutase causes cells to resist doxorubicin therapy

Oncology - Vascular endothelial growth factor modulates the migration of breast cancer

Ophthalmology - Drug-induced eye inflammation can cause vision loss if not caught early enough

Orthopedic Oncology - Researchers report the remission of an epithelioid hemangioma of bone

Osteosarcoma - Case report: Postradiation osteosarcoma after latency period of 3 years

Ovarian Cancer - Modified coxsackie-adenovirus receptor increases adenoviral transgene expression

Ovarian Cancer - Synergistic effects were achieved by Apo2L/TRAIL and cisplatin combination

Ovarian Tumor - Case report: 10-year-old girl presents with rare sclerosing stromal tumor of the ovary

Oxidative Stress - A new method measures oxidation products like oxysterols and alpha-tocopherol

Pancreatic Cancer - Multislice spiral CT can give diagnostic detail and determine resectability

Parathyroid Cancer - Molecular markers, Ki-67 and p27, may distinguish carcinoma from adenoma

Patient Care - Cancer patients and their relatives disagree on the quality of support

Pediatric Cancer - Promising approaches are being tested in pediatric cancer

Pelvic Sarcoma - Some pelvic sarcoma types have a high sacroiliac infiltration risk

Phytomedicine - Dehydrocrotonin from Croton cajucara is cytotoxic to leukemia cells

Pituitary Tumor - Histological differences between pituicytoma and pilocytic astrocytoma outlined

Plant Antioxidant -  Rhoeo discolor extract is not genotoxic or mutagenic, but is antioxidant

Primary Melanoma - C-myc oncoprotein is a prognostic marker for intermediate-thickness melanoma

Prostate Cancer - Screening for prostate cancer

Prostate Epithelial Cells - Whey protein treatment increases glutathione, thus protects against oxidants

Public Water Disinfection - The toxicology of drinking water disinfection byproducts is to be assessed

Quality of Life - Hope was not altered by knowledge of disease status or pain in cancer patients

Quality of Life - Researchers measure quality of palliative care in surviving family members

Radiation Delivery - Gamma Knife Center treats 1000th patient

Retinoblastoma - Two products of Ink4a-Arf regulate retinoblastoma protein

Rhabdomyosarcoma - Gene that drives apoptosis also plays key role in development of skeletal muscle

Solid Tumors - Cyclin A1 is expressed at different levels in many tumors

Squamous Cell Carcinoma -  Helicobacter pylori infection may be a risk for malignancy in head and neck

Squamous Cell Carcinoma - Inhibition of caspase-9 and Apaf-1 function may occur in cisplatin resistance

Squamous Lung Cancer - Magnolol has antiproliferative and antiapoptotic effects in a cell line

TGF-Beta Resistance - Downregulation of Smad3 leads to resistance to TGF-beta-induced growth arrest

Terminal Cancer - Survival estimates are accurate and linked symptomatically to peripheral edema

Thermotherapy - Monte Carlo simulation aids treatment planning, monitoring

Thyroid Cancer - An adenovirus encoding for rat protein suppresses human thyroid carcinoma

Thyroid Cancer - Cip-1 presence enhances apoptosis induced by manumycin and paclitaxel

Thyroid Carcinoma - Tumor histological subtypes have different Ret chimeric transcripts

Thyroid Liposarcoma - Case report: Liposarcoma of the thyroid gland

Toxicity - Probability of toxicity estimated in phase I trials

Trichosporon Asahii - Voriconazole is successful in treating a patient with acute myeloid leukemia

Tumor Targets - Some heparin derivatives are angiostatic

Tumorigenesis - Selective inhibitors of COX-2 may be effective in preventing and treating cancer

Urology - Adenoviral-mediated retinoblastoma 94 localizes to bladder cancer cells

Urology - Piroxicam and chemotherapy combine to diminish urinary bladder cancer

Urothelial Neoplasms - Controversies exist in classification and grading of urothelial neoplasms

Vertebral Metastases - Predicting risk of fracture and epidural impingement may help patient management

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