Oncology
Manganese superoxide dismutase causes cells to resist doxorubicin therapy
Published in Cancer Weekly, April 8th, 2003
According to a study from the United States, "overexpression of manganese superoxide dismutase (MnSOD) has been postulated as one possible mechanism of protection from oxidative damage and free radicals. Doxorubicin treatment induces oxygen free radicals, leading to cytotoxicity and myelosuppression. The present study was performed to determine whether over-expression of MnSOD may play a role in resistance to doxorubicin."
"Retroviral constructs having the human MNSOD gene in the sense orientation and the neomycin phosphotransferase gene (NEO (R) ) as a selectable marker...
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Source: Cancer Weekly (2003-04-08)
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