Published in Cancer Weekly, April 8th, 2003
According to a study from the United States, "retinoblastoma (RB)94, which lacks the NH2-terminal 112 amino acid residues of the full-length RB protein (RB110), is a more potent tumor and growth suppressor than RB110."
"In this study, Ad-RB94, but not Ad-RB110, produced marked growth inhibition, cytotoxicity, caspase-dependent apoptosis, and G(2)-M block in the human RB-negative, telomerase-positive bladder cancer cell line UM-UC14. This effect was completely inhibited by pretreatment with caspase inhibitors (p<0.0001)," stated X.Q. Zhang and coauthors, University of Texas,...
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